Targeted suppression of SPP1 inhibits tumor invasion and metastasis in NRF2 hyperactivated cisplatin resistant HNSCC
Mutsuki Kawabe, Sujuan Yang, Lorena I. Gomez Bolanos, Shiro Takamatsu, Sylvia Flores, Patricia D. Castro, Tsung‐You Tsai, Arisa Nishikawa Kaga, Kento Okamoto, Mitchell J. Frederick, Vlad Constantin Sandulache, Humam N. Kadara, Jeffrey N. Myers, Abdullah A. Osman
This study shows that suppressing SPP1 improves cisplatin sensitivity and inhibits tumor invasion and metastasis in NRF2-hyperactivated cisplatin-resistant HNSCC.
Journal of Translational Medicine · May 22, 2026Peer-reviewedCancer Biology