Preservation and Clonal Behavior of Extrachromosomal DNA in Patient-Derived Xenograft Models of Childhood Cancers
Rishaan Kenkre, Owen S. Chapman, Eugene Yui-Ching Chow, Jens Luebeck, Yan Yuen Lo, Megan Rose Paul, Wenshu Zhang, Jill P. Mesirov, Vineet Bafna, Kevin Yip, Jon D. Larson, Robert J. Wechsler‐Reya, Lukas Chávez
This study compares ecDNA prevalence, conservation, and clonal dynamics in PDX models and primary tumors of childhood cancers, finding high sequence conservation and selective growth advantage of ecDNA-positive clones.
Genome Medicine · May 28, 2026Peer-reviewedGenomics