Kexin Sun

A Time-Resolved Single-Cell Atlas Reveals Infection-Status, Age-, and Sex-Dependent Immune Responses Drive Viral Disease Severity

This study uses time-resolved single-cell RNA sequencing in mice to show age and sex influence immune responses and viral disease severity through altered gene expression and inflammation.

Therapeutic Peptide SS-31 Modulates Membrane Binding and Aggregation of Alpha-Synuclein and Restores Impaired Mitochondrial Function

This study shows SS-31 reduces alpha-synuclein membrane binding, aggregation, and mitochondrial dysfunction in neuroblastoma cells.

Temporal Dynamics and Adaptive Mechanisms of Microbial Communities: Divergent Responses and Network Interactions

This study examines how microbial communities respond to short-term environmental changes, revealing distinct temporal patterns and network dynamics in prokaryotic and eukaryotic groups.

Early cell cycle genes in cortical organoid progenitors predict interindividual variability in infant brain growth trajectories

The paper links early cell cycle gene expression in cortical organoids to interindividual variability in infant brain growth trajectories.

Cross-site reproducibility of human cortical organoids reveals consistent cell type composition and architecture

This study shows that human cortical organoids generated across multiple sites using a harmonized protocol consistently produce similar cell types and structures, though with some site-specific differences in size and stress markers.

Contribution of spontaneous mutations to quantitative and molecular variation at the highly repetitive rDNA locus in yeast

The paper quantifies mutation and selection impacts on rDNA copy number variation in yeast, finding high mutational variance and stabilizing selection.