Natural variation of the streptococcal Group A carbohydrate biosynthesis genes impacts host-pathogen interaction
Kim Schipper, Sara M. Tamminga, Nicholas R. Murner, Matthew A. Davies, Paul Berkhout, Debra E. Bessen, Astrid Hendriks, Natalia Korotkova, Yvonne Pannekoek, Nina M. van Sorge
The paper identifies genetic variation in the gacA-L cluster of S. pyogenes and shows that inactivating mutations in gacH reduce GroP decoration, affecting host-pathogen interactions.
Microbial Genomics · Jul 17, 2025Peer-reviewedMicrobiology