SARS-CoV2 genome analysis of Indian isolates and molecular modelling of D614G mutated spike protein with TMPRSS2 depicted its enhanced interaction and virus infectivity
Sunil K. Raghav, Arup Ghosh, Jyotirmayee Turuk, Sugandh Kumar, Atimukta Jha, Swati Madhulika, Manasi Priyadarshini, Viplov Kumar Biswas, P. Sushree Shyamli, Bharati Singh, Neha Singh, Deepika Singh, Ankita Datey, Kiran Avula, Shuchi Smita, , ILS COVID-19 Team
The paper analyzes SARS-CoV-2 genome sequences from Indian isolates, identifies clade distribution and transmission routes, and shows the D614G mutation enhances spike protein interaction with TMPRSS2, increasing viral infectivity.
Frontiers in Microbiology · Nov 23, 2020Peer-reviewedGenomics