Author

Kiran Kumar

Broad Institute

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Biology Disciplines

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Genomics· 3 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Assay:whole-genome sequencing· 3 Research Focus:differential expression· 2 Research Focus:variant calling· 2 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Approach:mixed model· 1

Frequent Co-Authors

Alexander Martinez‐FundichelyiD· 3 shared Ana Dueso-BarrosoiD· 3 shared Andrew J DunfordiD· 3 shared Andy G. LynchiD· 3 shared Barbara HutteriD· 3 shared Benedikt BrorsiD· 3 shared Cheng‐Zhong ZhangiD· 3 shared Chip StewartiD· 3 shared

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2020-2021 · peak 3/yr

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10 top collaborators · 45 mutual co-author links

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3 shared papersGenomics

Alexander Martinez‐FundichelyORCID

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4 papers

Recent·Most cited

Molecular docking and molecular dynamics simulation of the anticancer active ligand from Mimosa pudica to the Fibronectin Extra Domain A (EDA).

Mayank Kohli, C. Kamatchi, Kiran Kumar, Shivaji Bole

The paper investigates the anticancer potential of ligands from Mimosa pudica through molecular docking and dynamics simulations against Fibronectin Extra Domain A.

bioRxiv · Jul 30, 2021 · PreprintBioinformatics

Genomic footprints of activated telomere maintenance mechanisms in cancer

Lina Sieverling, Chen Hong, Sandra D. Koser, Philip Ginsbach, Kortine Kleinheinz, Barbara Hutter, Delia M. Braun, Isidro Cortés‐Ciriano, Ruibin Xi, Rolf Kabbe, Peter J. Park, Roland Eils, Matthias Schlesner, PCAWG-Structural Variation Working Group, Kadir C. Akdemir, , Rehan Akbani

The paper analyzes whole-genome sequencing data from cancer samples to identify genomic footprints of telomere maintenance mechanisms, finding specific telomere variant repeat patterns associated with ATRX/DAXX mutations.

Nature Communications · Feb 5, 2020Peer-reviewedGenomics

Spatial Genome Organization as a Framework for Somatic Alterations in Human Cancer

Kadir Caner Akdemir, Victoria T. Le, Sahaana Chandran, Yilong Li, Roel G.W. Verhaak, Rameen Beroukhim, Peter J. Campbell, Lynda Chin, Jesse R. Dixon, P. Andrew Futreal, PCAWG Structural Variation Working Group, Kadir C. Akdemir, Eva G. Álvarez, Adrian Baez‐Ortega, Paul C. Boutros, , Ludmil B. Alexandrov

The paper examines how somatic structural variations affect TAD boundaries and gene regulation in human cancers using whole genome sequencing data.

Nature Genetics · Feb 5, 2020Peer-reviewedGenomics

Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing

Isidro Cortés-Ciriano, Jake June-Koo Lee, Ruibin Xi, Dhawal S. Jain, Youngsook Lucy Jung, Lixing Yang, Dmitry A. Gordenin, Leszek J. Klimczak, Cheng‐Zhong Zhang, David S. Pellman, PCAWG Structural Variation Working Group, Kadir Caner Akdemir, Eva G. Álvarez, Adrian Baez‐Ortega, Rameen Beroukhim, , Kenneth Aldape

This study analyzes chromothripsis in 2,658 cancers using whole-genome sequencing, finding it prevalent across multiple cancer types with complex structural alterations.

Nature Genetics · Feb 5, 2020Peer-reviewedGenomics