Mechanistically Defined Epoxide- and Aziridine-2-carboxamide Electrophiles Enable Stereoselective Covalent RNA Modulation
Chungen Li, Xueyi Yang, Jingsong Shan, Kyle A. Dickerson, Noah A. Springer, Nikhil C. Munshi, Robert Batey, Matthew David Disney
This paper introduces epoxide- and aziridine-2-carboxamide electrophiles that covalently target RNA with stereoselectivity, demonstrating their application to RNA targets like r(CUG)exp repeats and FMN riboswitches.
bioRxiv · Jan 16, 2026 · PreprintBiochemistry