A pathological phosphorylation pattern enhances taucooperativity on microtubules and facilitates tau filamentassembly
Xiangyu Fan, Joey B. Truong, Kyoko Okada, Henry Lin, Kassandra M. Ori-McKenney, Richard J. McKenney
The paper investigates how specific phosphorylation patterns of tau affect microtubule binding, cooperativity, and filament assembly in tauopathies, revealing that pattern, not level, drives filament formation.
Communications Biology · Aug 21, 2026Peer-reviewedBiochemistry