A niche-specific role for ArlRS enables Staphylococcus aureus growth within Kupffer cells
Josefien W. Hommes, Lindsey M. Orthner, Fardau van der Wal, Ronald S W. Flannagan, Raymond Shim, L Barron, Mai Dao, Íñigo Lasa, Alexande R Horswill, David E. Heinrichs, Bas G. J. Surewaard
This study identifies ArlRS as essential for Staphylococcus aureus intracellular replication within Kupffer cells, highlighting its role in systemic infection and suggesting it as a therapeutic target.
bioRxiv · Oct 10, 2026 · PreprintMicrobiology