Cooperative conformational transitions and the temperature dependence of enzyme catalysis
E. J. Walker, C. J. Hamill, R. M. Crean, M. S. Connolly, A. K. Warrender, K. L. Kraakman, E. J. Prentice, A. Steyn-Ross, M. Steyn-Ross, C. R. Pudney, M. W. van der Kamp, L. A. Schipper, A. J. Mulholland, V. L. Arcus
This study investigates the temperature dependence of enzyme catalysis by analyzing MalL and its mutants, showing cooperative conformational transitions and introducing models to explain non-Arrhenius behavior.
bioRxiv · Jul 6, 2023 · PreprintBiochemistry