The Sodium/Glucose Cotransporter 2 Inhibitor Empagliflozin Inhibits Long QT 3 Late Sodium Currents in a Mutation Specific Manner
L. Lunsonga, M. Fatehi, W. Long, A. Barr, B. E. Gruber, A. Chattopadhyay, K. Barakat, A. G. Edwards, P. E. Light
This paper investigates how empagliflozin affects late sodium currents in specific LQT3 mutations, finding it selectively inhibits these currents in some mutations but not others.
bioRxiv · Apr 15, 2024Pharmacology & Toxicology