High-throughput differentiation of human blood vessel organoids reveals overlapping and distinct functions of the cerebral cavernous malformation proteins
Dariush Skowronek, Robin A. Pilz, Valeriia V. Saenko, Lara Mellinger, Debora Singer, Silvia Ribback, Anja Weise, Kevin Claaßen, Christian Büttner, Emily M Brockmann, Christian Andreas Hübner, Thiha Aung, Silke Haerteis, Sander Bekeschus, Arif Bülent Ekici, , Matthias Rath
This study uses blood vessel organoids to compare gene expression and cellular behavior in CCM1, CCM2, and CCM3 knockout models, revealing distinct functional roles that may explain differing disease severity.
Angiogenesis · Jun 6, 2025Peer-reviewedMolecular Biology