Domain-specific DNA binding activities of BRCA1 reveal substrate preferences for homologous recombination and telomere regulation
Kaitlin Lowran, Laura Campbell, Emma Cismas, Colin G. Wu
This study identifies DNA binding preferences of BRCA1 domains, showing DBD1 binds dsDNA and DBD2/BRCT bind ssDNA and G4, linking them to HR and telomere regulation.
Biochemistry · Sep 4, 2025Peer-reviewedBiochemistry