Stoichiometric Encoding of Amplification Kinetics Enables High-Level Multiplexing in Single-Channel TaqMan Real-Time PCR
Louis Kreitmann, Kenny Malpartida-Cardenas, Ye Mao, Karolina Sobala, Zexuan Zhao, San Chun Hin, Anirudhha Hazarika, Ke Xu, Luca Miglietta, Zara Breese, Alison H. Holmes, Karen Brengel-Pesce, Laurent Drazek, Jesus Rodriguez-Manzano
This paper introduces a method to increase multiplexing in TaqMan qPCR by encoding target-specific information into amplification curves and decoding them with a transformer model, achieving 8-plex detection with high accuracy.
bioRxiv · Nov 6, 2026 · PreprintMolecular Biology