Miniaturized Traceless Staudinger Ligation Enables Direct-to-Biology Screening of Potent BRD4 PROTACs
Marko Mitrović, Leann Schüffner, Saran Aswathaman Sivashanmugam, Stefan Knapp, Kerstin Hiesinger
This paper develops a miniaturized traceless Staudinger ligation method to rapidly discover potent BRD4-targeting PROTACs by screening crude reaction mixtures directly in biological assays.
bioRxiv · Nov 10, 2026 · PreprintCancer Biology