Author

Lehang Li

Harbin Institute of Technology

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 1

Signature Assays, Organisms & Methods

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Approach:benchmark study· 1 Research Focus:benchmarking· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:perturbation response prediction· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

Binxing Fang· 1 shared Chuanyi Liu· 1 shared Fang YeiD· 1 shared Shaoming DuaniD· 1 shared Xinyi ZhangiD· 1 shared Xinyu Zha· 1 shared Yang CaoiD· 1 shared Yuhao ZhangiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 28 mutual co-author links

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1 shared paperBioinformatics

Binxing Fang

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1 paper

Recent·Most cited

A mechanism-annotated benchmark reveals limited fidelity to drug-response signatures in single-cell perturbation models

Lehang Li, Shaoming Duan, Xinyu Zha, Fang Ye, Yuhao Zhang, Xinyi Zhang, Yang Cao, Chuanyi Liu, Binxing Fang

This paper introduces a benchmark to evaluate single-cell drug perturbation models by assessing their fidelity to drug-response signatures, finding that expression similarity is a poor proxy for mechanism preservation.

bioRxiv · Aug 26, 2026 · PreprintBioinformatics