Author

Lei Dai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Evolutionary Biology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Assay:proteomics· 3 Research Focus:protein folding & dynamics· 2 Approach:statistical model· 2 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:virus· 1

Frequent Co-Authors

James O. Lloyd-Smith· 2 shared Nicholas C. WuiD· 2 shared Ren SuniD· 2 shared Arunachalam Ramaiah· 1 shared C. Anders Olson· 1 shared Christian D. Huber· 1 shared Deisy Contreras· 1 shared Ergang Wang· 1 shared

Activity by Year

2016-2016 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersEvolutionary Biology

James O. Lloyd-Smith

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Adaptive potential of a drug-targeted viral protein as a function of environmental stress

Lei Dai, Yushen Du, Hangfei Qi, Christian D. Huber, Nicholas C. Wu, Ergang Wang, James O. Lloyd-Smith, Ren Sun

The paper quantifies the adaptive potential of HCV NS5A protein mutations under drug selection and environmental stress, finding increased beneficial mutations and fitness costs.

bioRxiv · Sep 30, 2016 · PreprintEvolutionary Biology

Comparative analysis of protein evolution and RNA structural changes in the genome of pre-epidemic and epidemic Zika virus

Arunachalam Ramaiah, Lei Dai, Deisy Contreras, Sanjeev Sinha, Ren Sun, Vaithilingaraja Arumugaswami

This study compares protein evolution and RNA structural changes in pre-epidemic and epidemic Zika virus strains to identify adaptation mechanisms to the human host.

bioRxiv · Apr 26, 2016 · PreprintMicrobiology

Adaptation in protein fitness landscapes is facilitated by indirect paths

Nicholas C. Wu, Lei Dai, C. Anders Olson, James O. Lloyd-Smith, Ren Sun

The paper experimentally characterizes a protein fitness landscape, finding that indirect adaptation paths through extra dimensions can bypass evolutionary traps caused by epistasis.

bioRxiv · Mar 22, 2016Evolutionary Biology