Squalene as a Candidate Signalling Molecule: Computational Evidence for a Predicted KEAP1 Interaction and Implications for Stress-Induced Altruistic Stem-Cell Niche Protection
Partheevjyoti Dutta, Upasha Sarmah, Lekhika Pathak, Partha Jyoti Saikia, Debduti Dattta, Seema Bhuyan, Bikul Das
This paper investigates the structural feasibility of squalene interacting with the KEAP1 Kelch domain using molecular docking and provides a hypothesis for its role in NRF2 regulation under stress.
bioRxiv · Nov 4, 2026 · PreprintCancer Biology