Neurodegeneration Risk Factor, EIF2AK3 (PERK), Influences Tau Protein Aggregation
Goonho Park, Ke Xu, Leon Chea, Kyle Kim, Lance A. Safarta, Keon‐Hyoung Song, Jian Wu, Soyoung Park, Hyejung Min, Nobuhiko Hiramatsu, Jaeseok Han, Jonathan H. Lin
This study shows that PERK activity prevents tau aggregation and that reduced PERK signaling increases tau neuropathology in tauopathies.
Journal of Biological Chemistry · Dec 20, 2022Peer-reviewedNeuroscience