Proteome-wide profiling reveals compartment-specific RNA buffering of protein aggregation during stress
Johanna Franziska Seidler, Fabienne Thelen, Nadine Bianca Wäber, Jan Weber, Leon Lohle, Thomas Timm, Günter Lochnit, Jochen Blom, Alexander Goesmann, Katja Sträßer, Cornelia Kilchert
The paper uses R-DeeP to show stress-induced compartment-specific RNA buffering of protein aggregation in yeast, with nuclear RNA retention protecting nuclear proteins from aggregation.
bioRxiv · Nov 6, 2026 · PreprintCell Biology