Deep models of protein evolution in time generate realistic evolutionary trajectories and functional proteins
Antoine Koehl, Sebastian Prillo, Matthew Liu, J. T. Xiong, Lillian Weng, David F. Savage, Yun S. Song
PEINT simulates realistic protein evolution by modeling sequence changes over time, generating functional proteins that retain enzymatic activity.
bioRxiv · Feb 20, 2026 · PreprintEvolutionary Biology