Spatial mapping of immunosuppressive cancer-associated fibroblast gene signatures in H&E-stained images using additive multiple instance learning
Miles Markey, Juhyun Kim, Zvi Goldstein, Ylaine Gerardin, Jacqueline A. Brosnan‐Cashman, Syed Ashar Javed, Dinkar Juyal, Harshith Pagidela, Limin Yu, Bahar Rahsepar, John Abel, Stephanie R. Hennek, Archit Khosla, Amaro N Taylor-Weiner, Chintan Parmar
This paper introduces aMIL, a machine learning method that predicts CAF gene signatures from H&E images, revealing spatial patterns linked to immunosuppression in tumors.
Modern Pathology · Apr 11, 2025Peer-reviewedCancer Biology