π-MNovo improves de novo peptide sequencing through microbial-domain adaptation and evidence-guided candidate selection
Jingwen Ye, Xing Zhang, Boyan Sun, Tianze Ling, Zhendong Liang, Jingyi Dong, Yuan Zheng, Hui Jin, Liming Jin, Zikai Hao, Leyuan Li, Cheng Chang
π-MNovo improves de novo peptide sequencing for metaproteomics by adapting to microbial spectra and selecting candidates based on evidence, achieving higher recall than existing models.
bioRxiv · Sep 24, 2026 · PreprintBioinformatics