Analysis of Rare Coding Variation Identifies New Genetic Contributors to Schizophrenia
Julia Sealock, Connor Dowd, Calwing Liao, Robert Ye, Daniel P. Howrigan, F. Kyle Satterstrom, Chiara Auwerx, Soyeon Kim, Cong Huai, Lin He, Melkam Alemayehu Kebede, Stella Gichuru, Rehema M. Mwende, Charles R. J. C. Newton, Nastassja Koen, , Akena Dickens
Ultra-rare damaging coding variants in 87,959 schizophrenia cases and 150,587 controls implicate 40 genes (16 exome-wide, 24 at 5% FDR), half overlapping autism, developmental delay or bipolar genes.
bioRxiv · Sep 21, 2026 · PreprintGenetics✦ In-depth digest