Disruption of the VEGFR3-HSPG2 induces lymphatic reflux dysfunction and sepsis
Yiming Zhang, Linfeng Liu, Wei Guo, Shunshun Wang, Xinyi Wu, Yanxu Jiang, Puhong Zhang, Jianguang Wang, 金胜威
The paper identifies lymphatic reflux dysfunction as a driver of sepsis by showing that VEGFR3-SOX18-HSPG2-heparan sulfate disruption impairs lymphatic barrier function and promotes systemic inflammation.
bioRxiv · Jan 29, 2026 · PreprintMolecular Biology