Archetype analysis of lung adenocarcinoma premalignancy links heterogeneity in premalignant lesions to diverging features of invasive disease
Kelley E. Anderson, Linh My Tran, Kostyantyn Krysan, Yohana Kefella, Lingge Yu, Gregory A. Fishbein, Erika F. Rodriguez, Maryam Shabihkhani, Daniel P. Stefanko, Emily J. Green, Gang Liu, Hanqiao Liu, Sherry Zhang, Erin Kane, Mitra Mehrad, , Jennifer Beane
This study identifies four molecular archetypes of lung adenocarcinoma premalignant lesions using bulk RNA and exome sequencing, linking proliferation-associated features to aggressive tumor outcomes.
Molecular Cancer Research · May 6, 2026Peer-reviewedCancer Biology