Using XCiMS to Quantify the Benefits of Ion Mobility Spectrometry for Untargeted Metabolomics
Lingjue Wang, Kevin Cho, Junjie Yang, Ethan Stancliffe, Michaela Schwaiger-Haber, Clark S Hofstrand, Triston Groff, James N. Dodds, Leah P. Shriver, Dhanalakshmi S. Anbukumar, Erin Shammel Baker, Gary J. Patti
The paper develops XCiMS software to analyze LC-IMS-MS data and evaluates how ion mobility spectrometry improves untargeted metabolomics by reducing chimeric spectra and providing CCS values.
bioRxiv · Oct 26, 2026 · PreprintBioinformatics