Author

Lisa Bachmann

Ruhr University Bochum

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:CRISPR screen· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

David Marks· 3 shared Thorsten MülleriD· 3 shared Alexander GeidiesiD· 2 shared Jannis Anstatt· 2 shared Lucia Gallego VillarejoiD· 2 shared Natalie HeineniD· 2 shared Elisabeth Schröder· 1 shared Konstanze F. WinklhoferiD· 1 shared

Activity by Year

2021-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersMolecular Biology

David Marks

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Fast and reliable sgRNA efficiency testing using HIReff

David Marks, Jannis Anstatt, Lisa Bachmann, Lucia Gallego Villarejo, Alexander Geidies, Thorsten Müller

The paper introduces HIReff, a method for efficiently testing sgRNA performance in CRISPR/Cas9 experiments, showing it is faster, cheaper, and more sensitive than traditional assays.

bioRxiv · Sep 15, 2021 · PreprintMolecular Biology

The method of choice to knock-in large inserts via CRISPR

David Marks, Lisa Bachmann, Lucia Gallego Villarejo, Alexander Geidies, Natalie Heinen, Jannis Anstatt, Thorsten Müller

This study compares methods for knocking-in large DNA fragments using CRISPR, finding that HDR with CRISPR is the most reliable and effective approach.

bioRxiv · Jul 1, 2021 · PreprintMolecular Biology

Amyloid precursor protein causes fusion of promyelocytic leukemia nuclear bodies in human hippocampal areas with high plaque load

David Marks, Natalie Heinen, Lisa Bachmann, Sophia Meermeyer, Michelle Werner, Lucia Gallego, Stephanie Nolte, Peter Hemmerich, Verian Bader, Konstanze F. Winklhofer, Elisabeth Schröder, Shirley K. Knauer, Thorsten Müller

The paper shows APP-CT fragments form nuclear aggregates with PML and FE65 in aged human brains, but not in cerebral organoids, and these aggregates are reduced in Alzheimer's disease regions with high plaque load.

Acta Neuropathologica Communications · Apr 13, 2021Peer-reviewedNeuroscience