Author

Liwei Chen

Agency for Science, Technology and Research

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:DNA methylation· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Wei Leong ChewiD· 2 shared Abdul Jalil RufaihahiD· 1 shared Alfredo Franco‐ObregóniD· 1 shared Bing Shao ChiaiD· 1 shared Binny Priya Sesurajan· 1 shared Choong Tat KengiD· 1 shared Citra Nurfarah Zaini MattariD· 1 shared I. Sujuandy· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersMolecular Biology

Wei Leong ChewORCID

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2 papers

Recent·Most cited

Modeling Adeno-Associated Viral Vector 6-mediated In Vivo Gene Delivery to Expanded Non-Mobilized Haemopoietic Stem Cells from Transfusion dependent Thalassemia Patients in a Humanized Mouse

Janani Ramesh, Karthikeyan Kandasamy, Nur Nazneen Binte Yusof, I. Sujuandy, Choong Tat Keng, Liwei Chen, Bing Shao Chia, Min Liu, Zhisheng Her, Marek Kukumberg, Kian Chuan Sia, Siti Humairah Mohd Rodhi, Zhen Ying Fu, Abdul Jalil Rufaihah, Alfredo Franco‐Obregón, , Citra Nurfarah Zaini Mattar

This study demonstrates the feasibility of using dual-ssAAV6 vectors for in vivo gene delivery to HSC from thalassemia patients in a humanized mouse model, showing efficient transduction and long-term persistence.

bioRxiv · Jun 17, 2025 · PreprintMolecular Biology

Precise and programmable C:G to G:C base editing in genomic DNA

Liwei Chen, Jung Eun Park, Peter Paa, Priscilla D. Rajakumar, Yi Ting Chew, Swathi N. Manivannan, Wei Leong Chew

This paper develops C:G to G:C base editors to correct specific SNPs in human cells, achieving up to 37% editing efficiency and 90% specificity.

bioRxiv · Jul 21, 2020 · PreprintSynthetic Biology