Author

Louise Thiry

Montreal Neurological Institute and Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Neuroscience· 5

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Research Focus:cell type annotation· 5 Organism:human· 5 Research Focus:differential expression· 4 Approach:experimental assay· 4 Assay:bulk RNA-seq· 3 Approach:statistical model· 3 Research Focus:cell-cell communication· 2 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Stefano StifaniiD· 5 shared Thomas M. DurcaniD· 2 shared Ye Man Tang· 2 shared Jean-Pierre Clément· 1 shared Julien SiroisiD· 1 shared Massimo PandolfoiD· 1 shared Michael R. Fiorini· 1 shared Nisha S. PulimoodiD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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5 shared papersNeuroscience

Stefano StifaniORCID

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5 papers

Recent·Most cited

Microglia from Friedreich Ataxia patients are intrinsically primed for neuroinflammation

Ye Man Tang, Rita Lo, Louise Thiry, Michael R. Fiorini, Sali Farhan, Massimo Pandolfo, Stefano Stifani

This study shows that microglia from Friedreich Ataxia patients have an intrinsic pro-inflammatory phenotype due to FXN deficiency, identifying potential therapeutic targets.

bioRxiv · Jul 21, 2026 · PreprintNeuroscience

Dysregulated expression of inflammasome and extracellular matrix genes in C9orf72-ALS/FTD microglia

Nisha S. Pulimood, Louise Thiry, Ye Man Tang, Stefano Stifani

This study identifies dysregulated ECM and inflammasome genes in C9orf72-HRE microglia, linking them to non-cell autonomous neurodegeneration in ALS/FTD.

bioRxiv · Feb 13, 2025 · PreprintNeuroscience

Generation of human iPSC-derived phrenic-like motor neurons to model respiratory motor neuron degeneration in ALS

Louise Thiry, Julien Sirois, Thomas M. Durcan, Stefano Stifani

This paper describes a method to generate human phrenic-like motor neurons from iPSCs to model ALS-related respiratory neuron degeneration.

Communications Biology · Feb 28, 2024Peer-reviewedNeuroscience

Optimization of long-term human iPSC-derived spinal motor neuron culture using a dendritic polyglycerol amine-based substrate

Louise Thiry, Jean-Pierre Clément, Rainer Haag, Timothy E. Kennedy, Stefano Stifani

This study develops a dPGA substrate to improve long-term culture of h-iPSC-derived motor neurons for studying viability, molecular identity, and electrophysiological activity.

ASN NEURO · Jan 1, 2022Peer-reviewedNeuroscience

Characterization of human-iPSCs derived spinal motor neurons by single-cell RNA sequencing

Louise Thiry, Regan Hamel, Stefano Pluchino, Thomas M. Durcan, Stefano Stifani

The paper uses single-cell RNA sequencing to characterize human iPSC-derived spinal motor neuron subtypes and identifies their molecular profiles.

Neuroscience · May 4, 2020Peer-reviewedNeuroscience