Lu Gan

Development of an HK-fbp1-based vaccine platform against Cryptococcus neoformans

This study develops and evaluates an HK-fbp1-based vaccine platform against Cryptococcus neoformans, showing superior protection compared to HK-H99 in multiple immunization settings.

A lenvatinib-resistance-derived transcriptional program identifies metabolic identity remodeling associated with unfavorable survival in hepatocellular carcinoma

This paper identifies a transcriptional program from lenvatinib-resistant HCC cells that correlates with poor survival in an independent patient cohort, highlighting metabolic identity remodeling.

Spatial vascular/BTB remodeling and malignant-state plasticity in glioblastoma

This study identifies spatially distinct vascular and BTB remodeling programs in glioblastoma and explores malignant-state plasticity across tumor compartments.

Reciprocal regulation of m6A modification and miRNA production machineries via phase separation-dependent and -independent mechanisms

Clinical manifestations and phenotypic analysis of new ANK1 gene mutations in 12 Chinese children with hereditary spherocytosis

The paper identifies new ANK1 gene mutations in 12 Chinese children with hereditary spherocytosis and evaluates their clinical and genetic implications.

Budding yeast chromatin is dispersed in a crowded nucleoplasm in vivo

This study uses electron cryotomography to show that budding yeast chromatin lacks 30-nm fibers and is in an open configuration, suggesting transcription regulation through local nucleosome interactions.