Mitochondria redistribution organizes the immunosuppressive tumor ecosystem
Azusa Terasaki, Alexis T. Weiner, Yuhao Tan, Viktória Szeifert, Keshav Bhatnagar, Cara Coleen Rada, Vishnu Shankar, Courtney Kernick, Mahnoor Mahmood, Lukas Wiggers, Viviana R. Rodrigues, Payam A. Gammage, Theodore L. Roth, Jeffrey D. Axelrod, Edgar G. Engleman, , Derick K. Okwan-Duodu
The paper shows cancer cells redistribute mitochondria to sustain immunosuppressive ecosystems, reprogramming immune cells and enhancing their own metabolic resilience.
bioRxiv · Nov 11, 2025 · PreprintCancer Biology