Structure and function of the bacterial protein toxin phenomycin
B. K. Hansen, C. K. Larsen, J. T. Nielsen, E. B. Svenningsen, L. B. Van, K. M. Jacobsen, M. Bjerring, R. K. Flygaard, L. B. Jenner, L. N. Nejsum, D. E. Brodersen, F. A. A. Mulder, T. Toerring, T. B. Poulsen
This study investigates phenomycin's mechanism of toxicity, showing it inhibits translation initiation, requires endosomal escape for toxicity, and identifies a critical structural loop for its activity.
bioRxiv · Nov 29, 2019Cell Biology