Reliable one-step assessment of IGHV mutational status and gene mutations in Chronic Lymphocytic Leukemia by capture-based high throughput sequencing.
Y. Le Bris, F. Thonier, A. Menard, O. Theisen, B. Mahe, A. Lok, S. Bouzy, M. C. Bene
This paper develops a single-step capture-based HTS method to simultaneously assess IGHV mutational status and TP53 mutations in CLL patients, validated on retrospective and prospective cohorts.
bioRxiv · Mar 9, 2022 · PreprintCancer Biology