C-terminal amides mark proteins for degradation via SCF/FBXO31
M. Muhar, J. Farnung, R. Hofmann, M. Cernakova, N. D. Sidiropoulos, J. W. Bode, J. E. Corn
The paper identifies C-terminal amides as signals for protein degradation via SCF/FBXO31, showing that oxidative stress generates these marks and a mutation disrupts this process, leading to toxicity.
bioRxiv · Jun 29, 2023Cell Biology