Allosteric receptor modulation of FFA2R turns natural agonists into potent activators of the superoxide generating neutrophil NADPH-oxidase
J. Martensson, A. Holdfeldt, M. Sundqvist, M. Gabl, L. Bjorkman, H. Forsman, C. Dahlgren
The paper shows that an allosteric modulator enhances acetate's ability to activate neutrophil NADPH-oxidase, increasing reactive oxygen species production.
bioRxiv · Mar 19, 2018Cell Biology