Catalytic antibodies in arrhythmogenic cardiomyopathy patients cleave desmoglein 2 and N-cadherin and impair cardiomyocyte cohesion
S. Yeruva, K. Stangner, A. Jungwirth, M. Hiermaier, M. Shoykhet, D. Kugelmann, M. Hertl, S. Egami, N. Ishii, H. Koga, T. Hashimoto, M. Weis, B. M. Beckmann, R. Biller, D. Schuettler, , J. Waschke
This study shows that catalytic autoantibodies in arrhythmogenic cardiomyopathy patients cleave desmoglein 2 and N-cadherin, impairing cardiomyocyte cohesion through p38MAPK activation.
bioRxiv · Feb 8, 2023Cell Biology