De novo design of mini-proteins as specific binders to PACAP-38, a key mediator of migraine
H. Yamaguchi, S. Suzuki, Y. Fujiyoshi, M. Isalan
This study designs mini-proteins that bind PACAP-38 with high affinity, showing improved potency and stability compared to earlier versions.
bioRxiv · Nov 2, 2026 · PreprintBioengineering