Protein stability engineering insights revealed by domain-wide comprehensive mutagenesis
A. Nisthal, C. Y. Wang, M. L. Ary, S. L. Mayo
The paper generates a comprehensive dataset of thermodynamic stability for nearly every single mutant of a small protein, revealing insights into mutational effects and improving stability prediction algorithms.
Proceedings of the National Academy of Sciences · Aug 1, 2019Peer-reviewedBiochemistry