Picomolar affinity antagonist and sustained signaling agonist peptide ligands for the adrenomedullin and calcitonin gene-related peptide receptors
J. M. Booe, M. L. Warner, A. A. Pioszak
The paper develops picomolar affinity antagonist and sustained signaling agonist peptides for AM and CGRP receptors, enhancing therapeutic potential through improved receptor binding and residence time.
bioRxiv · Feb 28, 2020Pharmacology & Toxicology