Loss of protein stability and function caused by P228L variation in NADPH-cytochrome P450 reductase linked to lower testosterone levels.
M. N. R. Velazquez, M. Noebauer, A. V. Pandey
The paper investigates the impact of the P228L variant in POR on protein stability and function, finding reduced catalytic activities and altered electron transfer.
bioRxiv · Aug 16, 2022Biochemistry