Discovery of a synthetic small molecule targeting the central regulator of Salmonella pathogenicity
A. Boudrioua, J. D. Joiner, I. Grin, T. Kronenberger, V. S. Korotkov, W. Steinchen, A. Kohler, S. Schminke, J.-C. Schulte, M. Pietsch, A. Naini, S. Kalverkamp, S.-K. Hotop, T. Coyle, C. Piselli, , S. Wagner
The paper identifies a synthetic small molecule, C26, that inhibits HilD, a key regulator of Salmonella secretion systems, thereby preventing bacterial invasion of host cells.
bioRxiv · Apr 29, 2024 · PreprintMicrobiology