Decreased IgG core fucosylation, a player in antibody-dependent cell-mediated cytotoxicity, is associated with autoimmune thyroid diseases
T. C. Martin, M. Simurina, M. Zabczynska, M. Martinic Kavur, M. Rydlewska, M. Pezer, K. Kozlowska, A. Burri, M. Vilaj, R. Turek-Jabrocka, M. Krnjajic-Tadijanovic, M. Trofimiuk-Muldner, A. Litynska, A. Hubalewska-Dydejczyk, I. Trbojevic-Akmacic, , G. Lauc
The paper investigates the association between IgG core fucosylation and autoimmune thyroid diseases, finding decreased fucosylation is linked to increased ADCC and TPOAb levels.
bioRxiv · Jul 4, 2018Immunology