p53 induces senescence in the unstable progeny of aneuploid cells
G. Rancati, M. Giam, C. K. Wong, J. S. Low, M. Sinelli, O. Dreesen
The paper shows that p53 induces senescence in the chromosomally unstable progeny of aneuploid cells, limiting their proliferation and reducing heterogeneity in aneuploid populations.
bioRxiv · Oct 25, 2019Cancer Biology