Small molecule FICD inhibitors suppress endogenous and pathologic FICD-mediated protein AMPylation
B. Chatterjee, M. Alam, A. Chakravorty, S. Lacy, J. Rech, C. L. Brooks, P. Arvan, M. Truttmann
This study identifies two small molecule inhibitors of FICD that suppress both endogenous and pathologic protein AMPylation, improving proinsulin processing in β cells.
bioRxiv · Jul 13, 2024Cell Biology