BiochemistrybioRxiv
Endo-lysosomal Aβ concentration and pH enable formation of Aβ oligomers that potently induce Tau missorting
M. P. Schützmann, F. Hasecke, S. Bachmann…·W. Hoyer
This study shows that endo-lysosomal pH and Aβ concentration drive Aβ oligomer formation, which induces Tau mislocalization and neuronal dysfunction in Alzheimer's disease.
DOI 10.1038/s41467-021-24900-4