Inhibition of p65 NF-κB enhances production of galactose-deficient IgA1 through suppression of C1GALT1 and SP1 in plasmablast-like cell subpopulations
Taylor Person, Maggie Phillips, Terri Rice, Stacy Hall, Bruce A Julian, Dana V. Rizk, Jan Novák, Colin Reily
The paper shows that inhibiting NF-κB/p65 increases galactose-deficient IgA1 production by reducing C1GALT1 expression and altering B cell subpopulations in IgAN patients.
Frontiers in Immunology · Oct 28, 2026Peer-reviewedImmunology