Author

Manabu Ishii

RIKEN Center for Biosystems Dynamics Research

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Biology Disciplines

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Bioinformatics· 2

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Research Focus:cell-cell communication· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:database / resource· 1 Approach:deep learning· 1 Organism:human· 1 Approach:matrix factorization· 1

Frequent Co-Authors

Itoshi NikaidoiD· 2 shared Koki TsuyuzakiiD· 2 shared

Activity by Year

2019-2023 · peak 1/yr

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2 top collaborators · 1 mutual co-author link

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2 shared papersBioinformatics

Itoshi NikaidoORCID

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2 papers

Recent·Most cited

BioinformaticsBMC BioinformaticsPeer-reviewedNov 7, 2023

scTensor detects many-to-many cell-cell interactions from single cell RNA-sequencing data

Koki Tsuyuzaki, Manabu Ishii, Itoshi Nikaido

scTensor identifies many-to-many cell-cell interactions from single-cell RNA-seq data by detecting triadic relationships not captured by conventional methods.

32 citations

scRNA-seqdeep learning

BioinformaticsbioRxivPreprintMar 4, 2019

✦ In-depth digest

Uncovering hypergraphs of cell-cell interaction from single cell RNA-sequencing data

Koki Tsuyuzaki, Manabu Ishii, Itoshi Nikaido

scTensor stacks ligand-receptor coexpression across cell-type pairs into a tensor and applies non-negative Tucker decomposition, recovering many-to-many cell-cell interactions that a label-permutation test missed in simulation.

54 citations

humanmouse