Author

Manasa Rapuru

Massachusetts General Hospital

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Genetics· 1

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Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Benjamin P. KleinstiveriD· 1 shared Dadi GaoiD· 1 shared Diane E. LucenteiD· 1 shared Elisabetta MoriniiD· 1 shared Iris N. FarnumiD· 1 shared James F. GusellaiD· 1 shared Jayla Ruliera· 1 shared Jennie C. L. RoyiD· 1 shared

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2024-2024 · peak 1/yr

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1 shared paperGenetics

Benjamin P. KleinstiverORCID

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1 paper

Recent·Most cited

PMS1 as a target for splice modulation to prevent somatic CAG repeat expansion in Huntington's disease

Zachariah L. McLean, Dadi Gao, Kevin Correia, Jennie C. L. Roy, Shota Shibata, Iris N. Farnum, Zoe Valdepenas-Mellor, Marina V. Kovalenko, Manasa Rapuru, Elisabetta Morini, Jayla Ruliera, Tammy Gillis, Diane E. Lucente, Benjamin P. Kleinstiver, Jong‐Min Lee, , James F. Gusella

This study shows splice modulators like branaplam reduce HTT CAG repeat expansion by affecting PMS1 expression, suggesting PMS1 as a new therapeutic target for Huntington's disease.

Nature Communications · Apr 12, 2024Peer-reviewedGenetics