Bicarbonate-free pH neutralization resensitizes ovarian cancer to chemotherapy and is tracked by 3T CEST MRI
Pooja A Patkulkar, Ankita Mandal, Sneha Noble, Roshni Parameswaran, Mandisa De, Shefali Jain, Shaik Imam Ahmed, Sanhita Sinharay
This study shows that inhibiting MCT1 and MCT4 with acriflavine neutralizes tumor acidosis, restores chemotherapy efficacy, and is monitored by 3T CEST MRI without using bicarbonate.
bioRxiv · Nov 4, 2026 · PreprintBioengineering